The K + channel GIRK2 is both necessary and sufficient for peripheral opioid‐mediated analgesia
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چکیده
منابع مشابه
The K+ channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia
The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction. In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids have repeatedly shown powerful analgesic effects; in some mouse models however, their actions remain ...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2013
ISSN: 1757-4676,1757-4684
DOI: 10.1002/emmm.201201980